Wuhan megalopolis, Changsha, Zhuzhou and Xiangtan urban group were determined to be a comprehensive reform trial region of resources-saving and environment-friendly society by National Development and Reform Committee by the end of 2007. Wuhan currently has officially started this construction. This paper analyzes the connotation, studies the advantages, disadvantages, opportunities and challenges, and presents a strategy to construct the resources-saving and environment-friendly society in Wuhan megalopolis.